CATH Domain 5eirA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.760	RNA Cap, Translation Initiation Factor Eif4e
	3.30.760.10	RNA Cap, Translation Initiation Factor Eif4e

Domain Context

CATH Clusters

Superfamily	RNA Cap, Translation Initiation Factor Eif4e
Functional Family	Eukaryotic translation initiation factor 4E

Enzyme Information

UniProtKB Entries (1)

IF4G1_HUMAN

Homo sapiens

Eukaryotic translation initiation factor 4 gamma 1

PDB Structure

PDB	5EIR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Soukarieh, F., Nowicki, M.W., Bastide, A., Poyry, T., Jones, C., Dudek, K., Patwardhan, G., Meullenet, F., Oldham, N.J., Walkinshaw, M.D., Willis, A.E., Fischer, P.M. Eur.J.Med.Chem.