CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.244 |
Protein N-terminal methyltransferase.
based on mapping to UniProt Q9BV86
(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N- (A,S)PK-[protein]. (2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl- L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
-!- This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved. -!- When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group. -!- When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations. -!- The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids. -!- Formerly EC 2.1.1.n5.
|
UniProtKB Entries (1)
| Q9BV86 |
NTM1A_HUMAN
Homo sapiens
N-terminal Xaa-Pro-Lys N-methyltransferase 1
|
PDB Structure
| PDB | 5E2A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev.
|
