CATH Classification
Domain Context
CATH Clusters
Superfamily | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit |
Enzyme Information
2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O00329
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
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UniProtKB Entries (2)
P23727 |
P85A_BOVIN
Bos taurus
Phosphatidylinositol 3-kinase regulatory subunit alpha
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O00329 |
PK3CD_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
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PDB Structure
PDB | 5DXU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J.Med.Chem.
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