CATH Domain 5dmrA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Gag-Pol polyprotein

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P03355 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.-.-	Acting on ester bonds. based on mapping to UniProt P03355
3.1.26.4	Ribonuclease H. based on mapping to UniProt P03355 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P03355
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P03355
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P03355 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (2)

Q8BWY3	ERF1_MOUSE Mus musculus Eukaryotic peptide chain release factor subunit 1
P03355	POL_MLVMS Moloney murine leukemia virus isolate Shinnick Gag-Pol polyprotein

PDB Structure

PDB	5DMR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus Tang, X., Zhu, Y., Baker, S.L., Bowler, M.W., Chen, B.J., Chen, C., Hogg, J.R., Goff, S.P., Song, H. Nat Commun