CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
| Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
| Functional Family |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt P32639
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
UniProtKB Entries (1)
| P32639 |
BRR2_YEAST
Saccharomyces cerevisiae S288C
Pre-mRNA-splicing helicase BRR2
|
PDB Structure
| PDB | 5DCA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.
Genes Dev.
|
