CATH Domain 5dcaA06

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.3380	Sec63 N-terminal domain-like fold
	1.10.3380.10	Sec63 N-terminal domain-like domain

Domain Context

CATH Clusters

Superfamily	Sec63 N-terminal domain-like domain
Functional Family	U5 small nuclear ribonucleoprotein helicase

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt P32639

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P32639

BRR2_YEAST

Saccharomyces cerevisiae S288C

Pre-mRNA-splicing helicase BRR2

PDB Structure

PDB	5DCA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Absmeier, E., Wollenhaupt, J., Mozaffari-Jovin, S., Becke, C., Lee, C.T., Preussner, M., Heyd, F., Urlaub, H., Luhrmann, R., Santos, K.F., Wahl, M.C. Genes Dev.