CATH Domain 5czvA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.3310

Domain Context

CATH Clusters

Superfamily	3.30.70.3310
Functional Family	Neurogenic locus notch homolog protein 3

Enzyme Information

UniProtKB Entries (1)

NOTC3_HUMAN

Homo sapiens

Neurogenic locus notch homolog protein 3

PDB Structure

PDB	5CZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Bernasconi-Elias, P., Hu, T., Jenkins, D., Firestone, B., Gans, S., Kurth, E., Capodieci, P., Deplazes-Lauber, J., Petropoulos, K., Thiel, P., Ponsel, D., Hee Choi, S., LeMotte, P., London, A., Goetcshkes, M., Nolin, E., Jones, M.D., Slocum, K., Kluk, M.J., Weinstock, D.M., Christodoulou, A., Weinberg, O., Jaehrling, J., Ettenberg, S.A., Buckler, A., Blacklow, S.C., Aster, J.C., Fryer, C.J. Oncogene