CATH Domain 5ccbA02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q96FX7
2.1.1.220	tRNA (adenine(58)-N(1))-methyltransferase. based on mapping to UniProt Q96FX7 S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA. -!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.

UniProtKB Entries (1)

TRM61_HUMAN

Homo sapiens

TRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

PDB Structure

PDB	5CCB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. Finer-Moore, J., Czudnochowski, N., O'Connell, J.D., Wang, A.L., Stroud, R.M. J.Mol.Biol.