CATH Domain 5bwrB01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.470	D-amino Acid Aminotransferase; Chain A, domain 1
	3.30.470.10	Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Superfamily	3.30.470.10
Functional Family	Branched-chain-amino-acid aminotransferase

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt O15382

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT2_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, mitochondrial

PDB	5BWR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. Bertrand, S.M., Ancellin, N., Beaufils, B., Bingham, R.P., Borthwick, J.A., Boullay, A.B., Boursier, E., Carter, P.S., Chung, C.W., Churcher, I., Dodic, N., Fouchet, M.H., Fournier, C., Francis, P.L., Gummer, L.A., Herry, K., Hobbs, A., Hobbs, C.I., Homes, P., Jamieson, C., Nicodeme, E., Pickett, S.D., Reid, I.H., Simpson, G.L., Sloan, L.A., Smith, S.E., Somers, D.O., Spitzfaden, C., Suckling, C.J., Valko, K., Washio, Y., Young, R.J. J.Med.Chem.