CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.330 | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Domain Context
CATH Clusters
| Superfamily | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
| Functional Family | aspartyl/asparaginyl beta-hydroxylase isoform X2 |
Enzyme Information
| 1.14.11.16 |
Peptide-aspartate beta-dioxygenase.
based on mapping to UniProt Q12797
Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L- aspartate + succinate + CO(2).
-!- Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
|
UniProtKB Entries (1)
| Q12797 |
ASPH_HUMAN
Homo sapiens
Aspartyl/asparaginyl beta-hydroxylase
|
PDB Structure
| PDB | 5APA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Nat Commun
|
