CATH Domain 5ansA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	7,8-dihydro-8-oxoguanine triphosphatase

Enzyme Information

3.6.1.56

2-hydroxy-dATP diphosphatase.

based on mapping to UniProt P36639

2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate.

-!- The enzyme hydrolyzes oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. -!- It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55).

3.6.1.55

8-oxo-dGTP diphosphatase.

based on mapping to UniProt P36639

8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.

-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

P36639

8ODP_HUMAN

Homo sapiens

7,8-dihydro-8-oxoguanine triphosphatase

PDB Structure

PDB	5ANS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. Kettle, J.G., Alwan, H., Bista, M., Breed, J., Davies, N.L., Eckersley, K., Fillery, S., Foote, K.M., Goodwin, L., Jones, D.R., Kack, H., Lau, A., Nissink, J.W., Read, J., Scott, J.S., Taylor, B., Walker, G., Wissler, L., Wylot, M. J.Med.Chem.