CATH Domain 5ajyA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1240	Phosphoglycerate mutase-like

Domain Context

CATH Clusters

Superfamily	Phosphoglycerate mutase-like
Functional Family	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

3.1.3.46	Fructose-2,6-bisphosphate 2-phosphatase. based on mapping to UniProt Q16875 Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).
2.7.1.105	6-phosphofructo-2-kinase. based on mapping to UniProt Q16875 ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.

UniProtKB Entries (1)

F263_HUMAN

Homo sapiens

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

PDB Structure

PDB	5AJY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. Boyd, S., Brookfield, J.L., Critchlow, S.E., Cumming, I.A., Curtis, N.J., Debreczeni, J., Degorce, S.L., Donald, C., Evans, N.J., Groombridge, S., Hopcroft, P., Jones, N.P., Kettle, J.G., Lamont, S., Lewis, H.J., Macfaull, P., Mcloughlin, S.B., Rigoreau, L.J.M., Smith, J.M., St-Gallay, S., Stock, J.K., Turnbull, A.P., Wheatley, E.R., Winter, J., Wingfield, J. J.Med.Chem.