CATH Domain 5aafA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Aurora kinase A

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14965

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965

AURKA_HUMAN

Homo sapiens

Aurora kinase A

PDB Structure

PDB	5AAF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent. Bavetsias, V., Perez-Fuertes, Y., Mcintyre, P.J., Atrash, B., Kosmopoulou, M., O'Fee, L., Burke, R., Sun, C., Faisal, A., Bush, K., Avery, S., Henley, A., Raynaud, F.I., Linardopoulos, S., Bayliss, R., Blagg, J. Bioorg.Med.Chem.Lett.