CATH Domain 5a2qD01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.300	GMP Synthetase; Chain A, domain 3
	3.30.300.20	K homology (KH) domain

Domain Context

CATH Clusters

Superfamily	3.30.300.20
Functional Family

Enzyme Information

4.2.99.18

DNA-(apurinic or apyrimidinic site) lyase.

based on mapping to UniProt P23396

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

P15880

RS2_HUMAN

Homo sapiens

40S ribosomal protein S2

PDB Structure

PDB	5A2Q
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution Quade, N., Boehringer, D., Leibundgut, M., Van Den Heuvel, J., Ban, N. Nat.Commun.