CATH Domain 4zzhA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1220	TPP-binding domain

Domain Context

CATH Clusters

Superfamily	TPP-binding domain
Functional Family	NAD-dependent histone deacetylase sirtuin-1

Enzyme Information

3.5.1.-

In linear amides.

based on mapping to UniProt Q96EB6

UniProtKB Entries (1)

SIR1_HUMAN

Homo sapiens

NAD-dependent protein deacetylase sirtuin-1

PDB Structure

PDB	4ZZH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Dai, H., Case, A.W., Riera, T.V., Considine, T., Lee, J.E., Hamuro, Y., Zhao, H., Jiang, Y., Sweitzer, S.M., Pietrak, B., Schwartz, B., Blum, C.A., Disch, J.S., Caldwell, R., Szczepankiewicz, B., Oalmann, C., Yee Ng, P., White, B.H., Casaubon, R., Narayan, R., Koppetsch, K., Bourbonais, F., Wu, B., Wang, J., Qian, D., Jiang, F., Mao, C., Wang, M., Hu, E., Wu, J.C., Perni, R.B., Vlasuk, G.P., Ellis, J.L. Nat Commun