1 keywords

CATH Domain 4xudA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P21964
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P21964
COMT_HUMAN
Homo sapiens
Catechol O-methyltransferase

PDB Structure

PDB 4XUD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
Harrison, S.T., Poslusney, M.S., Mulhearn, J.J., Zhao, Z., Kett, N.R., Schubert, J.W., Melamed, J.Y., Allison, T.J., Patel, S.B., Sanders, J.M., Sharma, S., Smith, R.F., Hall, D.L., Robinson, R.G., Sachs, N.A., Hutson, P.H., Wolkenberg, S.E., Barrow, J.C.
Acs Med.Chem.Lett.