CATH Domain 4xaqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2300	Response regulator

Domain Context

CATH Clusters

Superfamily	3.40.50.2300
Functional Family	Metabotropic glutamate receptor 3

Enzyme Information

UniProtKB Entries (1)

GRM2_HUMAN

Homo sapiens

Metabotropic glutamate receptor 2

PDB Structure

PDB	4XAQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. Monn, J.A., Prieto, L., Taboada, L., Pedregal, C., Hao, J., Reinhard, M.R., Henry, S.S., Goldsmith, P.J., Beadle, C.D., Walton, L., Man, T., Rudyk, H., Clark, B., Tupper, D., Baker, S.R., Lamas, C., Montero, C., Marcos, A., Blanco, J., Bures, M., Clawson, D.K., Atwell, S., Lu, F., Wang, J., Russell, M., Heinz, B.A., Wang, X., Carter, J.H., Xiang, C., Catlow, J.T., Swanson, S., Sanger, H., Broad, L.M., Johnson, M.P., Knopp, K.L., Simmons, R.M., Johnson, B.G., Shaw, D.B., McKinzie, D.L. J.Med.Chem.