CATH Domain 4x25A00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.30	Dynein light chain 2a, cytoplasmic

Domain Context

CATH Clusters

Superfamily	Dynein light chain 2a, cytoplasmic
Functional Family	Profilin

Enzyme Information

UniProtKB Entries (1)

PROF1_HUMAN

Homo sapiens

Profilin-1

PDB Structure

PDB	4X25
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for mutation-induced destabilization of profilin 1 in ALS. Boopathy, S., Silvas, T.V., Tischbein, M., Jansen, S., Shandilya, S.M., Zitzewitz, J.A., Landers, J.E., Goode, B.L., Schiffer, C.A., Bosco, D.A. Proc. Natl. Acad. Sci. U.S.A.