CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.460 | Beta Polymerase; domain 2 |
|
3.30.460.40 |
Domain Context
CATH Clusters
| Superfamily | 3.30.460.40 |
| Functional Family |
Enzyme Information
| 2.7.7.46 |
Gentamicin 2''-nucleotidyltransferase.
based on mapping to UniProt P0AE05
Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin.
-!- ATP, dATP, CTP, ITP and GTP can act as donors. -!- Kanamycin, tobramycin and sisomicin can also act as acceptors. -!- The nucleotidyl residue is transferred to the 2-hydroxy group of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
|
UniProtKB Entries (1)
| P0AE05 |
AADB1_KLEPN
Klebsiella pneumoniae
2''-aminoglycoside nucleotidyltransferase
|
PDB Structure
| PDB | 4WQL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio
|