CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10330 | Probable inorganic polyphosphate/atp-NAD kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Probable inorganic polyphosphate/atp-NAD kinase; domain 1 |
| Functional Family | Sphingosine kinase 2 |
Enzyme Information
| 2.7.1.91 |
Sphingosine kinase.
based on mapping to UniProt Q9NYA1
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.
|
| 2.3.1.- |
Transferring groups other than amino-acyl groups.
based on mapping to UniProt Q9NYA1
|
UniProtKB Entries (1)
| Q9NYA1 |
SPHK1_HUMAN
Homo sapiens
Sphingosine kinase 1
|
PDB Structure
| PDB | 4V24 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Sphingosine Kinase 1 with Pf-543.
Acs Med.Chem.Lett.
|