CATH Domain 4useA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	STE20-like serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O94804

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O94804

STK10_HUMAN

Homo sapiens

Serine/threonine-protein kinase 10

PDB Structure

PDB	4USE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Comprehensive Characterization of the Published Kinase Inhibitor Set. Elkins, J.M., Fedele, V., Szklarz, M., Abdul Azeez, K.R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.P., Roth, B.L., Al Haj Zen, A., Fourches, D., Muratov, E., Tropsha, A., Morris, J., Teicher, B.A., Kunkel, M., Polley, E., Lackey, K.E., Atkinson, F.L., Overington, J.P., Bamborough, P., Moller, S., Price, D.J., Willson, T.M., Drewry, D.H., Knapp, S., Zuercher, W.J. Nat.Biotechnol.