CATH Domain 4us0S01

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.870	Son of sevenless (SoS) protein; Chain S, domain 1
	1.20.870.10	Son of sevenless (SoS) protein Chain: S domain 1

Domain Context

CATH Clusters

Superfamily	Son of sevenless (SoS) protein Chain: S domain 1
Functional Family	son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

RASH_HUMAN

Homo sapiens

GTPase HRas

PDB Structure

PDB	4US0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. Winter, J., Anderson, M., Blades, K., Chresta, C., Embrey, K.J., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J.A., Wrigley, G. J.Med.Chem.