CATH Domain 4uipA04

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.220	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
	2.10.220.10	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P00533

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (3)

Q4G1L3	Q4G1L3_EPTBU Eptatretus burgeri Variable lymphocyte receptor B
P00533	EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
E0ACT6	E0ACT6_LISMN Listeria monocytogenes Internalin B

PDB Structure

PDB	4UIP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy. Lee, J., Choi, H., Yun, M., Kang, Y., Jung, J., Ryu, Y., Kim, T.Y., Cha, Y., Cho, H., Min, J., Chung, C., Kim, H. Angew.Chem.Int.Ed.Engl.