CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.20 | Single Sheet | |
2.20.70 | Ubiquitin Ligase Nedd4; Chain: W; | |
2.20.70.10 |
Domain Context
CATH Clusters
Superfamily | 2.20.70.10 |
Functional Family |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q13526
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
Q13526 |
PIN1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
|
PDB Structure
PDB | 4U85 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.
Neurobiol.Dis.
|