CATH Domain 4u6eA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.230	Creatine Amidinohydrolase
	3.90.230.10	Creatinase/methionine aminopeptidase superfamily

Domain Context

CATH Clusters

Superfamily	Creatinase/methionine aminopeptidase superfamily
Functional Family	Methionine aminopeptidase

Enzyme Information

3.4.11.18

Methionyl aminopeptidase.

based on mapping to UniProt P53582

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

-!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A.

UniProtKB Entries (1)

P53582

MAP11_HUMAN

Homo sapiens

Methionine aminopeptidase 1

PDB Structure

PDB	4U6E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases Arya, T., Reddi, R., Kishor, C., Ganji, R.J., Bhukya, S., Gumpena, R., McGowan, S., Drag, M., Addlagatta, A. J.Med.Chem.