CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.12 | Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 | |
1.10.12.10 | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
Domain Context
CATH Clusters
Superfamily | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
Functional Family | Enoyl-CoA delta isomerase 2, mitochondrial |
Enzyme Information
5.3.3.8 |
Delta(3)-Delta(2)-enoyl-CoA isomerase.
based on mapping to UniProt O75521
(1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
-!- The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. -!- Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system. -!- This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further. -!- The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. -!- The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
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UniProtKB Entries (1)
O75521 |
ECI2_HUMAN
Homo sapiens
Enoyl-CoA delta isomerase 2, mitochondrial
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PDB Structure
PDB | 4U19 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J.
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