CATH Domain 4tz4C01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.20	Peptide methionine sulfoxide reductase.

Domain Context

CATH Clusters

Superfamily	Peptide methionine sulfoxide reductase.
Functional Family	Cereblon, isoform CRA_c

Enzyme Information

UniProtKB Entries (1)

DDB1_HUMAN

Homo sapiens

DNA damage-binding protein 1

PDB Structure

PDB	4TZ4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex Chamberlain, P.P., Wang, M., Riley, M., Delker, S., Carmel, G., Miller, K., Lopez-Girona, A., Pagarigan, B., Leon, B., Rychak, E., Corral, L., Lopez-Girona, A., Ren, Y., Wang, M., Riley, M., Delker, S., Ito, T., Hideki, A., Mori, T., Handa, H., Hakoshima, T., Daniel, T.O., Miller, K., Cathers, B.E., Carmel, G., Pagarigan, B., Leon, B., Rychak, E., Corral, L., Ren, Y. To Be Published