CATH Domain 4tw6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q13451

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13451

FKBP5_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase FKBP5

PDB Structure

PDB	4TW6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective inhibitors of the FK506-binding protein 51 by induced fit. Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Fernandez-Vizarra, P., Sippel, C., Zannas, A.S., Draenert, R., Binder, E.B., Almeida, O.F., Ruhter, G., Uhr, M., Schmidt, M.V., Touma, C., Bracher, A., Hausch, F. Nat.Chem.Biol.