CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.30 | Glutaredoxin |
|
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
| Superfamily | Glutaredoxin |
| Functional Family | Iodothyronine deiodinase |
Enzyme Information
| 1.21.99.3 |
Thyroxine 5-deiodinase.
based on mapping to UniProt Q91ZI8
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H(+) = L-thyroxine + reduced acceptor.
-!- The enzyme activity has only been demonstrated in the direction of 5-deiodination. -!- This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. -!- Formerly EC 1.97.1.11.
|
UniProtKB Entries (1)
| Q91ZI8 |
IOD3_MOUSE
Mus musculus
Thyroxine 5-deiodinase
|
PDB Structure
| PDB | 4TR4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Proc.Natl.Acad.Sci.USA
|