CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.360 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.360 |
| Functional Family | Cytosolic non-specific dipeptidase |
Enzyme Information
| 3.4.13.18 |
Cytosol nonspecific dipeptidase.
based on mapping to UniProt Q96KP4
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
-!- Broad specificity, varying somewhat with source species. -!- Activated and stabilized by dithiothreitol and manganese. -!- Inhibited by bestatin and leucine. -!- Belongs to peptidase family M20. -!- Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.13.11, EC 3.4.13.13 and EC 3.4.13.15.
|
UniProtKB Entries (1)
| Q96KP4 |
CNDP2_HUMAN
Homo sapiens
Cytosolic non-specific dipeptidase
|
PDB Structure
| PDB | 4RUH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A
TO BE PUBLISHED
|
