CATH Domain 4rmhA01

Superfamily	TPP-binding domain
Functional Family	NAD-dependent deacetylase sirtuin-2

3.5.1.-

In linear amides.

based on mapping to UniProt Q8IXJ6

SIR2_HUMAN

Homo sapiens

NAD-dependent protein deacetylase sirtuin-2

PDB	4RMH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Rumpf, T., Schiedel, M., Karaman, B., Roessler, C., North, B.J., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., Jung, M. Nat Commun