CATH Domain 4r76D01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.220	Leucine Aminopeptidase, subunit E; domain 1
	3.40.220.10	Leucine Aminopeptidase, subunit E, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Aminopeptidase, subunit E, domain 1
Functional Family	M17 leucyl aminopeptidase

Enzyme Information

UniProtKB Entries (1)

Q8IL11_PLAF7

Plasmodium falciparum 3D7

M17 leucyl aminopeptidase

PDB Structure

PDB	4R76
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. Mistry, S.N., Drinkwater, N., Ruggeri, C., Sivaraman, K.K., Loganathan, S., Fletcher, S., Drag, M., Paiardini, A., Avery, V.M., Scammells, P.J., McGowan, S. J.Med.Chem.