CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.330 | Nucleotidyltransferases domain 2 |
Domain Context
CATH Clusters
| Superfamily | Nucleotidyltransferases domain 2 |
| Functional Family | protein-tyrosine kinase 2-beta isoform X1 |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q14289
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (2)
| P49024 |
PAXI_CHICK
Gallus gallus
Paxillin
|
| Q14289 |
FAK2_HUMAN
Homo sapiens
Protein-tyrosine kinase 2-beta
|
PDB Structure
| PDB | 4R32 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
J.Mol.Biol.
|