CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P26045
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P53778
MK12_HUMAN
Homo sapiens
Mitogen-activated protein kinase 12

PDB Structure

PDB 4QUM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation.
Chen, K.E., Lin, S.Y., Wu, M.J., Ho, M.R., Santhanam, A., Chou, C.C., Meng, T.C., Wang, A.H.J.
Sci.Signal.