CATH Domain 4qqnA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.160	Hnrnp arginine n-methyltransferase1
	2.70.160.11	Hnrnp arginine n-methyltransferase1

Domain Context

CATH Clusters

Superfamily	Hnrnp arginine n-methyltransferase1
Functional Family	protein arginine N-methyltransferase 3 isoform X2

Enzyme Information

2.1.1.-

Methyltransferases.

based on mapping to UniProt O60678

UniProtKB Entries (1)

ANM3_HUMAN

Homo sapiens

Protein arginine N-methyltransferase 3

PDB Structure

PDB	4QQN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Kaniskan, H.U., Eram, M.S., Zhao, K., Szewczyk, M.M., Yang, X., Schmidt, K., Luo, X., Xiao, S., Dai, M., He, F., Zang, I., Lin, Y., Li, F., Dobrovetsky, E., Smil, D., Min, S.J., Lin-Jones, J., Schapira, M., Atadja, P., Li, E., Barsyte-Lovejoy, D., Arrowsmith, C.H., Brown, P.J., Liu, F., Yu, Z., Vedadi, M., Jin, J. J. Med. Chem.