CATH Domain 4qg7A00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt Q6GJI9

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_STAAR

Staphylococcus aureus subsp. aureus MRSA252

Thymidylate kinase

PDB Structure

PDB	4QG7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Antibacterial inhibitors of gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region. Kawatkar, S.P., Keating, T.A., Olivier, N.B., Breen, J.N., Green, O.M., Guler, S.Y., Hentemann, M.F., Loch, J.T., McKenzie, A.R., Newman, J.V., Otterson, L.G., Martinez-Botella, G. J.Med.Chem.