CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.132 | Topoisomerase I; Chain A, domain 4 |
|
1.10.132.60 | DNA polymerase family B, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase family B, C-terminal domain |
| Functional Family | DNA polymerase |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P09884
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| P09884 |
DPOLA_HUMAN
Homo sapiens
DNA polymerase alpha catalytic subunit
|
PDB Structure
| PDB | 4Q5V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for inhibition of DNA replication by aphidicolin.
Nucleic Acids Res.
|