CATH Domain 4puqB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family	Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-

Phosphoric diester hydrolases.

based on mapping to UniProt Q9JJX7

UniProtKB Entries (1)

TYDP2_MOUSE

Mus musculus

Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB	4PUQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). Gao, R., Schellenberg, M.J., Huang, S.Y., Abdelmalak, M., Marchand, C., Nitiss, K.C., Nitiss, J.L., Williams, R.S., Pommier, Y. J.Biol.Chem.