CATH Domain 4ph4B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family	Phosphatidylinositol 3-kinase catalytic subunit type 3

Enzyme Information

2.7.1.137

Phosphatidylinositol 3-kinase.

based on mapping to UniProt Q8NEB9

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

PK3C3_HUMAN

Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3

PDB Structure

PDB	4PH4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Dowdle, W.E., Nyfeler, B., Nagel, J., Elling, R.A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., Cantwell, J., Luu, C., Cornella-Taracido, I., Harrington, E., Fekkes, P., Lei, H., Fang, Q., Digan, M.E., Burdick, D., Powers, A.F., Helliwell, S.B., D'Aquin, S., Bastien, J., Wang, H., Wiederschain, D., Kuerth, J., Bergman, P., Schwalb, D., Thomas, J., Ugwonali, S., Harbinski, F., Tallarico, J., Wilson, C.J., Myer, V.E., Porter, J.A., Bussiere, D.E., Finan, P.M., Labow, M.A., Mao, X., Hamann, L.G., Manning, B.D., Valdez, R.A., Nicholson, T., Schirle, M., Knapp, M.S., Keaney, E.P., Murphy, L.O. Nat.Cell Biol.