CATH Classification
Domain Context
CATH Clusters
| Superfamily | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
| Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit |
Enzyme Information
| 2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P42336
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
|
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42336
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
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UniProtKB Entries (1)
| P27986 |
P85A_HUMAN
Homo sapiens
Phosphatidylinositol 3-kinase regulatory subunit alpha
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PDB Structure
| PDB | 4OVV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of nSH2 regulation and lipid binding in PI3K alpha.
Oncotarget
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