CATH Domain 4ncsA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family	Neuraminidase 3

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt Q9Y3R4

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q9Y3R4

NEUR2_HUMAN

Homo sapiens

Sialidase-2

PDB Structure

PDB	4NCS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights. Buchini, S., Gallat, F.X., Greig, I.R., Kim, J.H., Wakatsuki, S., Chavas, L.M., Withers, S.G. Angew.Chem.Int.Ed.Engl.