CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.420 | Ricin (A subunit); domain 1 |
|
3.40.420.10 | Ricin (A subunit), domain 1 |
Domain Context
CATH Clusters
| Superfamily | Ricin (A subunit), domain 1 |
| Functional Family |
Enzyme Information
| 3.2.2.22 |
rRNA N-glycosylase.
based on mapping to UniProt Q7DI68
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
UniProtKB Entries (2)
| Q7DJJ2 |
Q7DJJ2_ECOLX
Escherichia coli
Shiga toxin 2 B subunit
|
| Q7DI68 |
Q7DI68_ECO57
Escherichia coli O157:H7
Shiga toxin 2 A-subunit
|
PDB Structure
| PDB | 4M1U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor.
J.Biol.Chem.
|