CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.830 | Cytochrome Bc1 Complex; Chain A, domain 1 |
|
3.30.830.10 | Metalloenzyme, LuxS/M16 peptidase-like |
Domain Context
CATH Clusters
| Superfamily | Metalloenzyme, LuxS/M16 peptidase-like |
| Functional Family | Insulin-degrading enzyme |
Enzyme Information
| 3.4.24.56 |
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.
|
UniProtKB Entries (1)
| P05067 |
A4_HUMAN
Homo sapiens
Amyloid-beta precursor protein
|
PDB Structure
| PDB | 4M1C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
To be Published
|