CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 10A

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9Y233
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9Y233
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

Q9Y233
PDE10_HUMAN
Homo sapiens
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB 4LLX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
Recht, M.I., Sridhar, V., Badger, J., Bounaud, P.Y., Logan, C., Chie-Leon, B., Nienaber, V., Torres, F.E.
J Biomol Screen