CATH Domain 4jpgC01

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1380	Pyruvate Kinase; Chain: A, domain 1
	3.40.1380.20	Pyruvate kinase, C-terminal domain

Superfamily	Pyruvate kinase, C-terminal domain
Functional Family	Pyruvate kinase

2.7.1.40

Pyruvate kinase.

based on mapping to UniProt P14618

ATP + pyruvate = ADP + phosphoenolpyruvate.

-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

KPYM_HUMAN

Homo sapiens

Pyruvate kinase PKM

PDB	4JPG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Guo, C., Linton, A., Jalaie, M., Kephart, S., Ornelas, M., Pairish, M., Greasley, S., Richardson, P., Maegley, K., Hickey, M., Li, J., Wu, X., Ji, X., Xie, Z. Bioorg.Med.Chem.Lett.