1 keywords

CATH Domain 4i5iB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1600 SIR2/SIRT2 'Small Domain'
Homologous Superfamily 3.30.1600.10 SIR2/SIRT2 'Small Domain'

Domain Context

CATH Clusters

Superfamily SIR2/SIRT2 'Small Domain'
Functional Family NAD-dependent protein deacetylase sirtuin-1

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q96EB6

UniProtKB Entries (1)

Q96EB6
SIR1_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-1

PDB Structure

PDB 4I5I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
Zhao, X., Allison, D., Condon, B., Zhang, F., Gheyi, T., Zhang, A., Ashok, S., Russell, M., MacEwan, I., Qian, Y., Jamison, J.A., Luz, J.G.
J.Med.Chem.