CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.210 | Beta Polymerase; domain 3 |
|
3.30.210.10 | DNA polymerase, thumb domain |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase, thumb domain |
| Functional Family | DNA nucleotidylexotransferase |
Enzyme Information
| 3.1.11.- |
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P09838
|
| 2.7.7.31 |
DNA nucleotidylexotransferase.
based on mapping to UniProt P09838
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Nucleoside may be ribo- or deoxyribo-.
|
UniProtKB Entries (1)
| P09838 |
TDT_MOUSE
Mus musculus
DNA nucleotidylexotransferase
|
PDB Structure
| PDB | 4I2I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism.
J.Mol.Biol.
|
