CATH Domain 4hsgA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.160	Hnrnp arginine n-methyltransferase1
	2.70.160.11	Hnrnp arginine n-methyltransferase1

Domain Context

CATH Clusters

Superfamily	Hnrnp arginine n-methyltransferase1
Functional Family	protein arginine N-methyltransferase 3 isoform X2

Enzyme Information

2.1.1.-

Methyltransferases.

based on mapping to UniProt O60678

UniProtKB Entries (1)

ANM3_HUMAN

Homo sapiens

Protein arginine N-methyltransferase 3

PDB Structure

PDB	4HSG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Liu, F., Li, F., Ma, A., Dobrovetsky, E., Dong, A., Gao, C., Korboukh, I., Liu, J., Smil, D., Brown, P.J., Frye, S.V., Arrowsmith, C.H., Schapira, M., Vedadi, M., Jin, J. J. Med. Chem.