CATH Domain 4hibA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Uridine monophosphate synthetase

Enzyme Information

2.4.2.10	Orotate phosphoribosyltransferase. based on mapping to UniProt P11172 Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. -!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
4.1.1.23	Orotidine-5'-phosphate decarboxylase. based on mapping to UniProt P11172 Orotidine 5'-phosphate = UMP + CO(2). -!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.

UniProtKB Entries (1)

UMPS_HUMAN

Homo sapiens

Uridine 5'-monophosphate synthase

PDB Structure

PDB	4HIB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. Purohit, M.K., Poduch, E., Wei, L.W., Crandall, I.E., To, T., Kain, K.C., Pai, E.F., Kotra, L.P. J.Med.Chem.