CATH Domain 4gs8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.830	Cytochrome Bc1 Complex; Chain A, domain 1
	3.30.830.10	Metalloenzyme, LuxS/M16 peptidase-like

Domain Context

CATH Clusters

Superfamily	Metalloenzyme, LuxS/M16 peptidase-like
Functional Family	Putative insulin-degrading enzyme

Enzyme Information

3.4.24.56

Insulysin.

based on mapping to UniProt P14735

Degradation of insulin, glucagon and other polypeptides. No action on proteins.

-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735

IDE_HUMAN

Homo sapiens

Insulin-degrading enzyme

PDB Structure

PDB	4GS8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Charton, J., Gauriot, M., Guo, Q., Hennuyer, N., Marechal, X., Dumont, J., Hamdane, M., Pottiez, V., Landry, V., Sperandio, O., Flipo, M., Buee, L., Staels, B., Leroux, F., Tang, W.J., Deprez, B., Deprez-Poulain, R. Eur.J.Med.Chem.